As a naturally occurring botanical extract, berberine is commonly isolated from plants such as Oregon grape, barberry, and goldenseal. Two other berberine-containing plants that are familiar to practitioners of Chinese medicine are Phellodendron chinense and Phellodendron amurense—the latter being the source of berberine in ALAmax Protect. Berberine is known as an alkaloid, and plants containing berberine have traditionally been used for their various health-promoting properties. Research has demonstrated that berberine helps regulate glucose and lipid metabolism, positively influences cell signaling, provides antioxidant support, and impacts immune health.[1-3] Of more recent interest is the influence of berberine on cardiometabolic health, including its effects on adenosine monophosphate-activated protein kinase (AMPK), gene transcription and signaling factors that influence adipose tissue differentiation, and hemoglobin A1c (HbA1c) levels.*
Alpha-Lipoic Acid (ALA)
ALA is a multifunctional antioxidant also known as thiotic acid. It has numerous effects that complement berberine. These effects include reducing oxidative stress, regenerating antioxidants, increasing glutathione synthesis, boosting antioxidant defense systems at the gene-expression level, stimulating AMPK activation,[12,13] affecting adipocyte differentiation, and increasing insulin-stimulated glucose disposal.[12,14,15] Furthermore, ALA inhibits nuclear factor-κB (Nf-κB), a transcription factor that activates many proinflammatory genes in the vasculature, making ALA an excellent pairing to berberine for cardiometabolic health.*
CinSulin® is a clinically proven, patented water extract of cinnamon (Cinnamomum cassia) shown to powerfully influence glucose metabolism. The unique, proprietary extraction and dehydration process for manufacturing CinSulin results in a concentrated (10:1) extract that minimizes undesirable substances, while retaining those that are health-promoting, such as type-A polyphenolic polymers. Cinnamon has been studied extensively for its roles in glucose uptake, glycogen synthesis, insulin action, and support for healthy blood lipids.[1,2] Anderson et al. demonstrated a 20-fold increase in glucose uptake in fat cells treated with water-soluble type-A polymers.
VegaPro™ is a pure, sweetener-free, vegetable protein blend sourced from nonGMO pea protein concentrate, pea protein isolate, and rice protein concentrate. This proprietary blend achieves an amino acid score of 100% and has excellent digestibility. Moderately high-protein, low-glycemic foods help increase feelings of satiety and support healthy body composition, healthy blood lipid metabolism, and postprandial glucose levels.[8-10] In an animal study comparing the effects of pea protein and casein on blood lipids, rats fed pea proteins showed a significant improvement in blood lipid levels compared to rats that were fed casein. The researchers also found that the pea proteins appeared to “affect cellular lipid homeostasis by upregulating genes involved in hepatic cholesterol uptake and by downregulating fatty acid synthesis genes.” These findings were echoed in a 2013 study performed in rats that tested the effects of a combination of pea protein and soluble fibers on cholesterol homeostasis and metabolism.*
Health Benefits of EPA/DHA
Research and studies have shown that omega-3 fatty acids antagonize arachidonic acid-induced eicosanoid formation; help generate resolvins and protectins to aid the body’s “cleanup” response to the arachidonic acid cascade; promote neurological health and mental functioning; and promote cardiovascular health, a balanced immune response, and healthy glucose and insulin metabolism.[3-15] Research suggests that it takes 2 g/day of DHA supplementation over a period of a month to saturate the plasma and three to six months of supplementation to saturate the tissues. Concentrations of DHA increased in breast milk within less than a week of supplementation.*
Ortho Biotic is a unique probiotic formula designed to deliver active organisms shown to promote healthy gut microflora, protect intestinal integrity and boost immune function. Included in this formula is Saccharomyces boulardii, an extensively researched microorganism shown to help restore microflora balance by enhancing commensal organism function. Each Ortho Biotic capsule provides seven proven probiotic strains chosen for their ability to withstand the harsh gastrointestinal (GI) environment and adhere to the intestinal tract to deliver superior results.
Deglycyrrhized Licorice Root Extract (DGL)
DGL is a form of licorice root that has been specially processed to contain only biologically active flavonoids, without glycyrrhizin. This allows for higher dosing of the active ingredient, which helps maintain a healthy mucosal surface.
Aloe Vera Leaf Gel Extract
A demulcent that has been used throughout history, aloe vera has long been known to promote a normal inflammatory response. Studies have shown aloe vera is specifically beneficial to the gastric mucosa, in part by its ability to balance stomach acid levels and promote healthy mucus production.
L-glutamine is a main source of fuel for the cells of the small intestines and essential to tissue repair throughout the body. Enterocytes use the amino acid to help maintain the health of the mucosa.
N-acetyl glucosamine is the acetylated form of glucosamine. It is a mucin precursor and has been shown to increase the production of mucus within the GI tract.
Zinc is an essential mineral widely recognized for its role in gut and immune health. Zinc has been shown to strengthen GI barrier function by supporting the structure of tight junctions.